Table 2. . Distribution of placental DNA methylation levels (%).
| Gene name |
Median (25th–75th percentile) |
p-value† | ||
|---|---|---|---|---|
| Total (n = 181) | Case (n = 80) | Control (n = 101) | ||
|
HSD11B2 |
13.58 (11.77–14.77) |
13.92 (12.25–15.25) |
13.25 (11.30–14.50) |
0.003** |
|
NR3C1 |
63.96 (59.79–68.63) |
64.11 (58.90–68.34) |
63.79 (60.34–68.71) |
0.620 |
|
WNT2 |
12.98 (8.49–43.01) |
12.53 (8.63–43.45) |
13.46 (8.42–43.17) |
0.678 |
| IGF2: | ||||
| – Pos.1 | 58.55 (55.72–61.49) | 57.92 (54.65–61.27) | 58.66 (56.74–61.87) | 0.128 |
| – Pos.2 |
45.77 (40.18–48.60) |
44.03 (35.96–47.69) |
46.35 (42.98–49.25) |
0.005** |
| IL6: | ||||
| – Pos.1 | 6.13 (4.71–8.27) | 6.23 (4.82–8.28) | 6.10 (4.54–8.28) | 0.796 |
| – Pos.2 |
14.92 (11.34–18.51) |
14.84 (12.04–18.22) |
15.00 (10.89–18.53) |
0.948 |
| AHRR: | ||||
| – Pos.1 | 57.20 (52.49–61.99) | 55.84 (51.23–60.07) | 57.95 (53.95–63.48) | 0.021* |
| – Pos.2 | 73.78 (67.97–80.39) | 72.06 (66.60–77.93) | 75.02 (69.88–80.91) | 0.075 |
| – Pos.3 | 41.23 (36.81–46.39) | 41.01 (36.71–46.00) | 41.44 (37.04–46.72) | 0.673 |
†p value calculated using the Mann–Whitney U test.
*p < 0.05; **p < 0.01.
Pos.1: The first studied CpG site; Pos.2: The second studied CpG site; Pos.3: The third studied CpG site.