Table 3. . Crude and adjusted association between DNA methylation and birth weight.

Methylation	Birth weight
	Crude model		Adjusted model†
	β (95% CI)	p-value	β (95% CI)	p-value
HSD11B2	-0.048 (-0.083 to -0.012)	0.009**	-0.027 (-0.053 to -0.002)	0.033*
NR3C1	0.008 (-0.005–0.021)	0.229	-0.003 (-0.012–0.006)	0.557
WNT2:
– High	-0.018 (-0.040–0.005)	0.121	-0.019 (-0.037 to -0.002)	0.034*
– Low	0.011 (-0.014–0.037)	0.387	0.010 (-0.005–0.025)	0.198
IGF2:
– Pos.1	0.017 (0.001–0.034)	0.043*	0.009 (-0.002 to 0.020)	0.125
– Pos.2	0.010 (-0.001–0.020)	0.072	0.008 (0.001–0.015)	0.026*
IL6:
– Pos.1	-0.003 (-0.032–0.026)	0.819	-0.008 (-0.027–0.011)	0.386
– Pos.2	0.006 (-0.010–0.021)	0.468	0.002 (-0.008–0.013)	0.683
AHRR:
– Pos.1	0.020 (0.006–0.033)	0.005**	0.010 (0.001–0.019)	0.027*
– Pos.2	0.010 (-0.001–0.022)	0.076	0.006 (-0.001–0.013)	0.086
– Pos.3	0.001 (-0.012–0.012)	0.956	0.004 (-0.003–0.012)	0.250

Methylation level of each gene was modeled as the independent variable associated with birth weight as the dependent variable.

^†Adjusted for gestational age, infant gender, birth type, prenatal vitamin use and environmental tobacco smoke during pregnancy.

*p < 0.05; **p < 0.01.

High: High WNT2 methylation group; Low: Low WNT2 methylation group; Pos.1: The first studied CpG site; Pos.2: The second studied CpG site; Pos.3: The third studied CpG site.