Table 4. . Crude and adjusted association between placental DNA methylation and birth length.

Methylation	Birth length
	Crude model		Adjusted model†
	β (95% CI)	p-value	β (95% CI)	p-value
HSD11B2	-0.162 (-0.302 to -0.022)	0.023*	-0.118 (-0.219 to -0.016)	0.023*
NR3C1	0.049 (-0.002–0.099)	0.059	0.008 (-0.029–0.045)	0.682
WNT2:
– High	-0.015 (-0.087–0.057)	0.679	-0.014 (-0.082–0.053)	0.671
– Low	-0.002 (-0.104–0.101)	0.976	-0.005 (-0.070–0.061)	0.886
IGF2:
– Pos.1	0.035 (-0.032–0.102)	0.301	0.008 (-0.039–0.056)	0.730
– Pos.2	0.028 (-0.013–0.068)	0.183	0.018 (-0.011–0.046)	0.226
IL6:
– Pos.1	-0.013 (-0.128–0.102)	0.824	-0.033 (-0.133–0.047)	0.411
– Pos.2	0.032 (-0.030–0.095)	0.309	0.008 (-0.035–0.052)	0.702
AHRR:
– Pos.1	0.039 (-0.017–0.095)	0.175	0.001 (-0.039–0.039)	0.933
– Pos.2	0.021(-0.026–0.068)	0.380	0.005 (-0.027–0.037)	0.772
– Pos.3	-0.023 (-0.071–0.024)	0.332	-0.004 (-0.036–0.029)	0.827

Methylation level of each gene was modeled as the independent variable associated with birth length as the dependent variable.

^†Adjusted for gestational age, birth type and environmental tobacco smoke during pregnancy

*p < 0.05.

High: High WNT2 methylation group; Low: Low WNT2 methylation group; Pos.1: The first studied CpG site; Pos.2: The second studied CpG site; Pos.3: The third studied CpG site.