Table 6. . Crude and adjusted odds ratios for placental DNA methylation and fetal growth restriction birth.
| Methylation |
Crude model |
Adjusted model† |
||
|---|---|---|---|---|
| OR (95% CI) | p -value | OR (95% CI) | p-value | |
| HSD11B2 | 1.208 (1.060–1.376) | 0.005** | 1.224 (1.047–1.430) | 0.011* |
|
NR3C1 |
0.989 (0.947–1.033) |
0.748 |
1.022 (0.967–1.079) |
0.444 |
| WNT2: | ||||
| – High | 1.060 (0.966–1.163) | 0.216 | 1.136 (1.007–1.281) | 0.037* |
| – Low |
0.979 (0.906–1.058) |
0.600 |
0.971 (0.872–1.081) |
0.971 |
| IGF2: | ||||
| – Pos.1 | 0.932 (0.879–0.988) | 0.018* | 0.932 (0.863–0.990) | 0.041* |
| – Pos.2 |
0.951 (0.917–0.987) |
0.008** |
0.947 (0.908–0.988) |
0.012* |
| IL6: | ||||
| – Pos.1 | 1.013 (0.922–1.113) | 0.794 | 1.020 (0.906–1.148) | 0.744 |
| – Pos.2 |
0.998 (0.949–1.050) |
0.947 |
0.995 (0.935–1.148) |
0.878 |
| AHRR: | ||||
| – Pos.1 | 0.947 (0.904–0.993) | 0.023* | 0.949 (0.895–1.006) | 0.079 |
| – Pos.2 | 0.967 (0.931–1.004) | 0.077 | 0.955 (0.910–1.002) | 0.060 |
| – Pos.3 | 0.992 (0.955–1.030) | 0.671 | 0.956 (0.909–1.006) | 0.083 |
†Adjusted for gestational age, prenatal vitamin use and environmental tobacco smoke during pregnancy.
*p < 0.05; **p < 0.01.
High: High WNT2 methylation group; Low: Low WNT2 methylation group; OR: Odds ratio; Pos.1: The first studied CpG site; Pos.2: The second studied CpG site; Pos.3: The third studied CpG site.