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Immunohistochemical stainings for toll-like receptor 2 (A) and toll-like receptor 4 (B) in normal colorectal mucosa. Weak TLR2 expression is present in the deeper parts of the crypt epithelium and moderate expression in uppermost part of the crypts and the surface (A). TLR4 expression shows a similar gradient, however, with a moderate expression in the lower parts of the crypts and strong in the surface (B). Reference lines, 50 μm. TLR: Toll-like receptor.
