Table 4.
Performance characteristics of two-dimensional shear wave elastography for staging liver fibrosis in patients with autoimmune liver diseases
| Cutoff, kPa | Se, % (95%CI) | Sp, % (95%CI) | PPV, % (95%CI) | NPV, % (95%CI) | LR+, ratio (95%CI) | LR-, ratio (95%CI) | |
| ≥ F2 | 9.71 | 81.7 (71.6-89.4) | 81.3 (63.6-92.8) | 91.8 (83.0-96.9) | 63.4 (46.9-77.9) | 4.4 (3.6-5.3) | 0.23 (0.10-0.5) |
| 7.22 | 93.9 (86.3-98.0) | 40.6 (23.7-59.4) | 80.2 (70.8-87.6) | 72.2 (46.5-90.3) | 1.6 (1.0-2.4) | 0.15 (0.06-0.4) | |
| 7.13 | 93.9 (86.3-98.0) | 37.5 (21.1-56.3) | 79.4 (70.0-86.9) | 70.6 (44.0-89.7) | 1.5 (1.0-2.4) | 0.16 (0.07-0.4) | |
| ≥ F3 | 13.21 | 83.0 (69.2-92.4) | 74.6 (62.5-84.5) | 69.6 (55.8-81.3) | 86.2 (74.6-93.9) | 3.3 (2.7-4.0) | 0.23 (0.1-0.5) |
| 9.12 | 95.7 (85.5-9.5) | 52.2 (39.7-64.6) | 58.4 (46.6-69.6) | 94.6 (81.5-99.4) | 2.0 (1.6-2.5) | 0.08 (0.02-0.3) | |
| 8.73 | 97.9 (88.7-99.9) | 49.3 (36.8-61.8) | 57.5 (45.9-68.5) | 97.1 (84.7-99.9) | 1.9 (1.5-2.5) | 0.04 (0.01-0.3) | |
| F4 | 16.31 | 87.0 (66.4-97.2) | 80.2 (70.6-87.8) | 52.6 (35.6-69.2) | 96.1 (88.9-99.2) | 4.4 (3.6-5.3) | 0.16 (0.05-0.5) |
| 11.72 | 95.7 (78.1-99.9) | 57.1 (46.3-67.5) | 36.1 (24.2-49.4) | 98.1 (89.8-100.0) | 2.2 (1.8-2.7) | 0.08 (0.01-0.5) | |
| 10.43 | 95.7 (78.1-99.9) | 48.4 (37.7-59.1) | 31.9 (21.2-44.2) | 97.8 (88.2-99.9) | 1.9 (1.5-2.3) | 0.09 (0.01-0.6) |
1
Cut-off values in patients with autoimmune liver diseases;
2
Cut-off values in patients with chronic hepatitis B;
3
Cut-off values in patients with chronic hepatitis C. Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio.