Table 1.

Risk for coronary artery disease in testicular cancer survivors regarding to different treatment modalities

Author (year)	N	Period of treatment	Median follow up (range), in years	Age at diagnosis (range)	Age at follow-up (range)	Risk for CAD (CI 95 %)	Treatment Modalities	Note
Meinardi et al.17 (2000)	87	Before 1987a	14 (10 to 20)	27 (17-36)	42 (30-50)	SIR=7.1 (1.9 to 18.3)	ChT	Age adjusted results. Older than 50 years at follow-up were excluded
Huddart et al.24 (2003)	992	1982-1992	10.2 (0 to 20.3)	31.7 (10-82)	44 (23-78)	RR=1.00 (reference) RR=2.59 (1.15 to 5.84) RR=2.40 (1.04 to 5.45) RR=2.78 (1.09 to 7.07)	Surveillance ChT ChT RT ChT and RT	Age adjusted results. Only 8.3 % of RT treated patients had also med. RT
Van der Belt- Dusebuot et al.11 (2006)	2339	1965-1995	18.4 (5 to 38.4)	38.3b (n.r.) 28.1c (n.r.)	59.8b (n.r.) 50.4c (n.r.)	SIR=0.94 (0.61 to 1.39) SIR=1.35 (0.97 to 1.83) SIR=1.07 (0.92 to 1.23) SIR=2.48 (1.77 to 3.37) SIR=0.92 (0.77 to 1.08) SIR=2.97 (1.73 to 4.77) SIR=1.83 (1.08 to 2.90)	Surveillance ChT RT RT – med RT – subdia RT – med. + ChT RT – subdia. + ChT	Patients with CAD before or within 5 years from diagnosis were excluded
Haughnes et al.12 (2010)	990	1980-1994	19 (13 to 28)	31 (15-53)	51 (31-69)	HR=1.0 (reference) HR=2.0 (0.64 to 6.1) HR=5.7 (1.9 to 17.1) HR=2.1 (0.78 to 5.4) HR=5.3 (1.5 to 18.3)	Surveillance ChT (CVB) ChT (BEP) RT ChT + RT	Age adjusted results. Patients with CAD before or within 2 years from diagnosis were excluded. Only 3 of 420 RT treated patients had also med. RT

BEP = bleomycin, etoposid, cisplatin; CAD = coronary artery disease; ChT = chemotherapy; CVB = cisplatin, etoposid, bleomycin; HR = hazard ratio; med. = mediastinal; N = number of patients; n.r. = not reported; RT =radiotherapy; RR = relative risk; SIR = standardized incidence ratio; subdia. = subdiaphragmatic;

^aAll patients treated with cisplatin based chemotherapy before 1987.

^bAge for seminoma patients.

^cAge for nonseminoma patients.