Figure 1.

In Vitro Bystander Effect between Muse-tk and GBM Cells

(A and B) Proliferation activity of U87 (A) and U251 (B) human GBM cells in medium containing 2 μg/mL GCV was significantly inhibited when the tumor cells were co-cultured with Muse-tk cells at an M/T ratio as low as 1:64 (mean ± SD). No proliferation inhibition of tumor cells was observed when the cells were not co-cultured with Muse-tk cells (M/T ratio of 0:1). (C) Real-time bystander effect between Muse-tk and U87 cells observed under a culture microscope is shown.