Table S4.

siRNA sequences used in PIEC RNAi testing of DNA–PK components

siRNA name	Mixed siRNA sequence, 5′-3′
Ku70 RNAi mixture
si-Ku70-1	CAGGUAUCUUCCUGGACUUdTdT
si-Ku70-2	GACGUUUAAUGUAAACACAdTdT
si-Ku70-3	GUCAAGAUGAGCCAUAAGAdTdT
Ku80 RNAi mixture
si-Ku80-1	CCUAUGAGUGUUUAGUGUAdTdT
si-Ku80-2	GAUGAAAUAUAUUCCUUUAdTdT
si-Ku80-3	CUAUUCAAGGGUUCCGCUAdTdT
DNA-PKcs RNAi mixture
si-PK-1	GAGGUUACGCAGACGAUUUdTdT
si-PK-2	GAAAGAUGAUGUUCACUCUdTdT
si-PK-3	CUUUGCAUAUGAGAUAAUUdTdT
Negative control	UUCUCCGAACGUGUCACGUTT