Table 3.
Cell cycle-regulated genes with characterized functionsa
Line | Process | G1 | S | G2 | G2/M | M |
---|---|---|---|---|---|---|
1 | Cell cycle control | rum1, csk1, mik1 | suc1, spd1, wee1, cig1 | cdc25 | cdc13, cdr1, nuc2, hcn1 | |
2 | DNA replication and nucleosome assembly | cdc18, pfh1, cdc1, cdt1, cdt2, pol1, cdc22, ssb1, suc22, mip1, cdm1 | hta1, hta2, htb1, hht1, hht2, hht3, hhf1, hhf2, hhf3 | cdc23, orc5 | cdc20, rfc2 | |
3 | Chromosome organization | rad21, dfp1, sds21, fin1, smc3, cut2, cnp1 | sds22 | hst4, spc24, dhp1, cid14, mis4, cut1 | cut17 | cnd1 |
4 | Polarized cell growth | pob1, cdc42, gar2 | fim1, cam1 | ppe1, sts5, pho1, pop3, csx2, hob3, pmr1 | ptc4 | |
5 | MT-based processes | scp3, alp31, klp8 | nak1 | dim1, pak1, sad1, alm1, alp14 | nda2, alp1 | klp5, tub1, klp6, mph1 |
6 | Cytokinesis | sid2, mob1, imp2, par2, spn2, mid2, cdc4 | aps1, rng2, mid1, sep1, myo52 | myo51, cdc11 | etd1, cdc15, myp2 plo1, rlc1 | |
7 | Mating and meiosis | mfm2, rgs1, spk1, ste6, srw1, byr2, isp6, cig2 | sap1, zfs1, mes1, pac2 | ste7, mam4, slp1 | ||
8 | RNA pol. subunit | rpb10, rpb3, rpb9 | ||||
9 | Amino acid biosynthesis | leu2, his3 | ||||
10 | Protein biogenesis | tif34 | tif51, tif6, tef3, sui1, rps2, rps1202, rpp201, rpp202, rpl901, rpl25a, rpl3202, rps13, rpl2701, rpl29, rpl3801 | rpl1603 | ||
11 | Transport/secretion | bet1, emp24, erv14, sec22, anc1 | rer1, sod2, clc1, fio1, ght3, ypt3, sec17 | arf1, n150, kap104, ght2, bfr1, nup124, nrf1, pmd1, mae1, pim1, apl1, pse1, sec72, sar1 | sec1 | sly1, abc1, sso1 |
12 | Lipid/sterol metabolism | erg7, cut6 | erg28, lsd1, ipk1 | bem46, gpi1 | ||
13 | Cell wall biogenesis | chs2, exg1, eng1, pmk1, bgs4 | cwl1, psu1, gmh2, bgs3, hsf1, atf1, gpx1, ctt1, sks2, mpr1, hsp9, wis4, wis1, csx1, sin1, hsp60, bip1 | exg2 | cwg2, ags1 | |
14 | Stress response | slm9 | ||||
15 | Carbohydrate metabolism | fum1 | scr1 | |||
16 | Ubiquitin modification | ubc15, ubc3 | pub1 | ubi4, ubi3, ubi1 | ubc11 | |
17 | DNA repair | msh6 | rad25, rdp1, top2, hus2 | ung1 | pms1, pac1, mus81 |
More information and relevant references on these genes can be obtained through the websites of the Sanger Centre GeneDB (http://www.genedb.org) and Incyte PombeDB (http://www.incyte.com/proteome)