Table S1.
MIC50 and MBC90 of Q203 and BDQ against H37Rv, five M. tuberculosis clinical isolates, and M. bovis bacillus Calmette–Guérin
| Strains | Q203 | BDQ | ||||
| MIC50 (nM) | MBC90 (nM) | MBC90/MIC50 (ratio) | MIC50 (nM) | MBC90 (nM) | MBC90/MIC50 (ratio) | |
| H37Rv | 1.5 ± 0.1 | >400 | >267 | 42.1 ± 1.3 | ≤500 | ≤12 |
| N0072 | 1.5 ± 0.1 | >400 | >267 | 132.5 ± 4.4 | ≤500 | ≤4 |
| N0052 | 2.5 ± 0.4 | >400 | >160 | 75.3 ± 7.6 | ≤500 | ≤7 |
| N0145 | 2.8 ± 0.4 | >400 | >142 | 51.0 ± 5.3 | ≤500 | ≤10 |
| N0155 | 2.6 ± 0.1 | n.d. | n.d. | 57.6 ± 1.5 | n.d. | n.d. |
| N0157 | 2.4 ± 0.2 | n.d. | n.d. | 120.2 ± 5.9 | n.d. | n.d. |
| Bacillus Calmette–Guérin | 1.5 ± 0.2 | >400 | >267 | 61.6 ± 3.4 | ≤500 | ≤8.5 |
The ratio between the MIC50 and the MBC90 is shown. Experiments were performed in triplicate and repeated at least once. MIC50 results are expressed as the mean ± SDs of a representative experiment. n.d., not determined.