Table 3.
Selected genes overexpressed in freshly isolated CD31+ cells compared with freshly isolated CD31- cells
| Gene name | Fold difference |
|---|---|
| Stem cell- and development-related genes | |
| SRY (sex determining region Y)-box (Sox) 17 | 43 |
| Mesenchyme homeo box 1 | 27 |
| LIM homeobox 6 | 22 |
| Endothelial-related genes | |
| Vascular epithelium-cadherin (CD144) | 168 |
| Platelet endothelial cell adhesion molecule (PECAM, CD31) | 134 |
| Claudin 5 (endothelial specific component of tight junctions) | 109 |
| Von Willebrand factor | 52 |
| Selectin E | 40 |
| Kinase insert domain receptor (KDR, VEGFR-2) | 28 |
| TEK tyrosine kinase (endothelial) | 24 |
| Ephrin-B2 | 15 |
| Fms-related tyrosine kinase 1 (Flt-1, VEGFR-1) | 13 |
| Angiotensin II receptor-like 1 | 13 |
| Thrombomodulin (CD141) | 9 |
| Endoglin (CD105) | 6 |
| Selectin P | 6 |
| Notch homolog 4 | 6 |
| Eph B4 | 4 |
| MHC and antigen presentation related genes | |
| Major histocompatibility complex, class II DR alpha | 186 |
| Major histocompatibility complex, class II DQ beta 1 | 159 |
| Major histocompatibility complex, class II DQ beta 2 | 74 |
| HLA complex p5 | 48 |
| Major histocompatibility complex, class II DR beta 3 | 28 |
| Major histocompatibility complex, class II DQ alpha 1 | 21 |
| Major histocompatibility complex, class II DP alpha 1 | 19 |
| Invariant chain (CD74 antigen) | 19 |
| Major histocompatibility complex, class II DM alpha | 10 |
| Cytokines and -receptors, growth factors and -receptors | |
| Duffy antigen receptor for chemokines (CD234) (expressed on erythrocytes and endothelium) | 362 |
| Hepatocyte growth factor receptor | 140 |
| G protein-coupled receptor 56 (EGF-TM7-like) | 131 |
| Chemokine (C-C motif) receptor-like 2 | 131 |
| Colony stimulating factor 3 (granulocyte) | 130 |
| Epidermal growth factor-seven transmembrane (EGF-TM7) 1 | 92 |
| Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains | 78 |
| Chemokine (C-C motif) ligand 15 | 52 |
| Interleukin 3 receptor alpha | 35 |
| Signal transduction and transcription related genes | |
| Ectopic viral integration site 1 | 91 |
| RAS guanyl releasing protein 3 (calcium- and DAG-regulated) | 61 |
| Liver receptor homolog 1 (nuclear receptor subfamily 5, group A, member 2) | 59 |
| Cdc42 effector protein 3 | 35 |
| Tumor-associated calcium signal transducer 2 | 30 |
| Others | |
| Alpha 6 integrin (CD49f) | 437 |
| Human immune associated nucleotide 2 | 254 |
| Matrix metalloproteinase 1 (interstitial collagenase) | 74 |
| Glia maturation factor gamma | 57 |
| v-ets erythroblastosis virus E26 oncogene-like (avian) | 51 |
| Myosin VIIA and Rab interacting protein | 48 |
| Carbonic anhydrase IV | 43 |
The table presents the 30 most highly overexpressed transcripts plus selected transcripts with presumed biological relationship with some of the most highly overexpressed transcripts. In addition, some transcripts with relevance to biology discussed in the text are presented. If a gene was represented with more than one probe in the list, the probe with the highest degree of differential expression was selected. The values represent the median from three donors.