Table 5.
Selected genes down-regulated in cultured ADASC compared with freshly isolated CD31- cells
| Gene name | Fold change |
|---|---|
| Cell cycle- and growth arrest-related genes | |
| Cyclin-dependent kinase inhibitor 1 C (p57, Kip2) | 32 |
| Growth arrest-specific 7 | 18 |
| Growth arrest and DNA-damage-inducible gamma | 18 |
| Growth arrest and DNA-damage-inducible beta | 14 |
| Stem cell- and development-related genes | |
| Wingless-type MMTV integration site family, member 11 | 75 |
| Frizzled-related protein | 20 |
| Dickkopf homolog 2 | 10 |
| Cytokine- and cytokine receptor—related genes | |
| Chemokine (C-X-C motif) ligand 14 | 1136 |
| Insulin-like growth factor 1 (somatomedin C) | 96 |
| Platelet-derived growth factor receptor-like | 86 |
| Suppressor of cytokine signaling 3 | 52 |
| Chemokine (C-X-C motif) ligand 3 | 31 |
| Interleukin 8 | 27 |
| Complement system | |
| Complement component 7 | 278 |
| Complement component D (adipsin) | 99 |
| Complement component 3 | 69 |
| Complement component H | 31 |
| Adipose tissue—related | |
| Apolipoprotein E | 146 |
| Apolipoprotein D | 128 |
| LR8 protein (VLDL receptor) | 111 |
| Fatty acid binding protein 4 | 52 |
| Apolipoprotein C1 | 43 |
| Peroxisome proliferative activated receptor, gamma (PPARγ) | 19 |
| Bone-related | |
| Osteoglycin (osteoinducive factor, mimecan) | 63 |
| Osteomodulin | 54 |
| Bone morphogenetic protein 2 | 38 |
| Cathepsin K | 9 |
| Cartilage- and extracellular matrix—related | |
| Dermatopontin | 191 |
| SPARC-like 1 | 182 |
| Tenomodulin protein | 50 |
| Cartilage intermediate layer protein | 41 |
| Glypican 3 | 39 |
| Matrix Gla protein | 34 |
| Collagen, type XIV, alpha 1 (undulin) | 15 |
| Nervous system—related | |
| Brain-specific protein | 131 |
| Neuralin 1 | 43 |
| EphA3 | 36 |
| Neuro-oncological ventral antigen 1 | 34 |
| Other genes | |
| FBJ murine osteosarcoma viral oncogene homolog B (Fos-B) | 315 |
| Cell adhesion molecule with homology to L1CAM (close homolog of L1) | 284 |
| H. sapiens mRNA full length insert cDNA clone EUROIMAGE 1630957 | 224 |
| CD14 antigen | 86 |
| WNT1 inducible signaling pathway protein 2 | 84 |
| Alcohol dehydrogenase 1B (class I), beta polypeptide | 84 |
| Periplakin | 70 |
| Myocilin (trabecular meshwork inducible glucocorticoid response) | 79 |
| Carboxypeptidase, vitellogenic-like | 64 |
| N-acetylated alpha-linked acidic dipeptidase 2 | 60 |
| Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 56 |
| Inter-alpha trypsin inhibitor heavy chain precursor 5 | 53 |
| RGC32 protein | 52 |
| Bone marrow stromal cell antigen 2 | 40 |
| CD44 antigen | 7 |
| CD34 antigen | 6 |
The table presents the 30 most highly overexpressed transcripts plus selected transcripts with presumed biological relationship with some of the most highly overexpressed transcripts. In addition, some transcripts with relevance to biology discussed in the text are presented. If a gene was represented with more than one probe in the list, the probe with the highest degree of differential expression was selected. The values represent the median from three donors.