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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Eur J Immunol. 2016 Oct;46(10):2454–2466. doi: 10.1002/eji.201546274

Fig. 4. I.v. MOG-induced tolerogenic phenotype of CD11c+CD11b+ DCs is abrogated by injection of clodronate-loaded liposomes.

Fig. 4

Mice immunized for EAE induction were i.v. injected with MOG or PBS, while PBS-loaded or clodronate-loaded liposomes were i.p. injected. Splenocytes and CNS infiltrating cells were isolated 21 days p.i. and analyzed by flow cytometry. (A) Expression of CD40, CD80, CD86 and IA in gated CD11c+CD11b+ DCs in splenocytes (left) and CNS infiltrating cells (right). (B) Results in (A) were analyzed and shown as mean ± SEM (n=3 each group). *p<0.05, ***p<0.001, two-way ANOVA test. One representative of 3 experiments is shown.