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. 2005 Mar;16(3):1200–1212. doi: 10.1091/mbc.E04-06-0523

Figure 3.

Figure 3.

Amino acid changes caused by ts mutations in the dhc-1 gene. The six AAA domains are shown as gray boxes. The first four AAA domains have conserved P-loops (black lines), whereas the fifth and sixth AAA domains have diverged P-loops (dashed black lines). The coiled-coil, microtubule-binding stalk region is shown as a black box. The dominant ts dhc-1 allele ct76 contains a mutation (G→A) that causes an A3027D replacement in the Box VI element within AAA4. Two other dominant ts dhc-1 alleles, ct42 and ct77, both contain the same base pair substitution (G→A), which results in a G2540E change in the third P-loop (underlined). The recessive ts dhc-1 allele or195 has a mutation that causes an H2157L replacement near the second P-loop (underlined; Hamill et al., 2002). Accession numbers: Drosophila, P37276; S. cerevisiae, P36022; and C. elegans, NP491363.