Figure 2.

Synthetic self-assembled nanoparticle systems for combination nanodrug delivery in neuroregenerative therapies.

(A) Cubosome nanoparticle with a dense core of periodically ordered bilayer lipid membranes, which may provide high encapsulation rate for both hydrophilic proteins or peptides and poor water soluble antioxidant substances; (B) vesicle-type nanocarrier, in which a single lipid bilayer membrane surrounds an aqueous core. The drug release properties and the encapsulation capacity of vesicular nanocarriers for hydrophobic and hydrophilic drug molecules differ from those of the cubosome nanocarriers.