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. 2017 Mar 31;8(23):37250–37262. doi: 10.18632/oncotarget.16763

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Copyright: © 2017 Argyros et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Synthesis of SAP from the available acid intermediate 1. Reagents and conditions: (a) DMF, EDCI, HOBt, NE_t3, rt: room temperature; (b) CH₂C_l2, TFA, rt. (B) NMR spectrum of SAP. (C) Key physical properties for SAP and sunitinib. (D) Representative positive electrospray ionization mass spectra of SAP showing the main ionized form (M+1, m/z 412.5). (E) MS/MS analysis of the parent ion with m/z 412.5 and the formation of product ions with m/z 283.3 and m/z 326.2 (F) LC/MRM chromatogram of SAP, demonstrating the presence of E and Z geometric isomers.