Table 3. Logistic regression analyses of associations between PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms and risk of type 2 diabetes.
| Genotype | Cases(n=502) | Controls(n=782) | Crude OR (95%CI) | P | Adjusted OR a (95%CI) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| PPARG rs1801282 C>G | ||||||||
| CC | 457 | 91.95 | 704 | 90.03 | 1.00 | 1.00 | ||
| CG | 40 | 8.05 | 76 | 9.72 | 0.80 (0.54-1.20) | 0.280 | 0.76(0.50-1.14) | 0.179 |
| GG | 0 | 0 | 2 | 0.26 | - | - | - | - |
| GC+GG | 40 | 8.05 | 78 | 9.98 | 0.79 (0.53-1.18) | 0.247 | 0.75 (0.50-1.12) | 0.164 |
| CC+GC | 497 | 100 | 780 | 99.75 | 1.00 | 1.00 | ||
| GG | 0 | 0 | 2 | 0.26 | - | - | - | - |
| G allele | 40 | 4.02 | 80 | 5.12 | ||||
| PPARG rs3856806 C>T | ||||||||
| CC | 278 | 55.94 | 474 | 60.61 | 1.00 | 1.00 | ||
| CT | 196 | 39.44 | 275 | 35.17 | 1.19 (0.94-1.51) | 0.140 | 1.17(0.92-1.48) | 0.204 |
| TT | 23 | 4.63 | 33 | 4.22 | 1.17 (0.67-2.03) | 0.583 | 1.19 (0.68-2.08) | 0.541 |
| CT+TT | 219 | 44.06 | 308 | 39.39 | 1.21 (0.97-1.52) | 0.098 | 1.19 (0.94-1.50) | 0.140 |
| CC+CT | 474 | 95.37 | 749 | 95.78 | 1.00 | 1.00 | ||
| TT | 23 | 4.63 | 33 | 4.22 | 1.10 (064-1.90) | 0.728 | 1.14 (0.65-1.97) | 0.653 |
| T allele | 242 | 24.35 | 341 | 21.80 | ||||
| PPARGC1A rs8192678 C>T | ||||||||
| CC | 138 | 27.77 | 250 | 31.97 | 1.00 | 1.00 | ||
| CT | 251 | 50.50 | 382 | 48.85 | 1.15 (0.89-1.49) | 0.296 | 1.12 (0.86-1.46) | 0.402 |
| TT | 108 | 21.73 | 150 | 19.18 | 1.26 (0.91-1.74) | 0.161 | 1.22 (0.88-1.69) | 0.240 |
| CT+TT | 269 | 54.12 | 532 | 68.03 | 1.22 (0.96-1.57) | 0.111 | 1.19 (0.93-1.1.53) | 0.178 |
| CC+CT | 389 | 78.27 | 632 | 80.82 | 1.00 | 1.00 | ||
| TT | 108 | 21.73 | 150 | 19.18 | 1.17 (0.89-1.54) | 0.269 | 1.15(0.87-1.52) | 0.334 |
| T allele | 467 | 46.98 | 682 | 43.61 | ||||
| PPARGC1A rs2970847 C>T | ||||||||
| CC | 310 | 62.37 | 485 | 62.02 | 1.00 | 1.00 | ||
| CT | 160 | 32.19 | 268 | 34.27 | 0.92 (0.72-1.17) | 0.495 | 0.93 (0.73-1.19) | 0.582 |
| TT | 27 | 5.43 | 29 | 3.71 | 1.43 (0.83-2.47) | 0.194 | 1.50 (0.87-2.60) | 0.148 |
| CT+TT | 187 | 37.63 | 297 | 37.98 | 0.99 (0.78-1.24) | 0.899 | 1.00 (0.79-1.27) | 0.979 |
| CC+CT | 470 | 94.57 | 753 | 96.29 | 1.00 | 1.00 | ||
| TT | 27 | 5.43 | 29 | 3.71 | 1.49 (0.87-2.55) | 0.144 | 1.55(0.90-2.68) | 0.112 |
| T allele | 214 | 21.53 | 326 | 20.84 | ||||
| PPARGC1A rs3736265 G>A | ||||||||
| GG | 380 | 76.61 | 557 | 71.41 | 1.00 | |||
| GA | 103 | 20.77 | 196 | 25.13 | 0.76(0.58-1.00) | 0.049 | 0.76(0.58-1.00) | 0.053 |
| AA | 13 | 2.62 | 27 | 3.46 | 0.70(0.36-1.37) | 0.295 | 0.74(0.37-1.46) | 0.378 |
| GA + AA | 116 | 23.39 | 223 | 28.59 | 0.76(0.59-0.99) | 0.041 | 0.77(0.59-1.00) | 0.050 |
| GG+GA | 483 | 97.38 | 753 | 96.54 | 1.00 | 1.00 | ||
| AA | 13 | 2.62 | 27 | 3.46 | 0.75(0.38-1.47) | 0.403 | 0.79(0.40-1.56) | 0.494 |
| A allele | 129 | 13.00 | 250 | 15.98 | ||||
| PPARGC1B rs7732671 G>C | ||||||||
| GG | 435 | 87.53 | 698 | 89.26 | 1.00 | 1.00 | ||
| GC | 61 | 12.27 | 81 | 10.36 | 1.20(0.84-1.70) | 0.323 | 1.20(0.84-1.72) | 0.314 |
| CC | 1 | 0.20 | 3 | 0.38 | 0.53(0.06-5.10) | 0.582 | 0.48(0.05-4.71) | 0.527 |
| GC+CC | 62 | 12.47 | 84 | 10.74 | 1.18(0.84-1.68) | 0.342 | 1.19(0.83-1.69) | 0.341 |
| GG+GC | 496 | 99.80 | 779 | 99.62 | 1.00 | 1.00 | ||
| CC | 1 | 0.20 | 3 | 0.38 | 0.52(0.05-5.05) | 0.576 | 0.47(0.05-4.66) | 0.520 |
| C allele | 63 | 6.34 | 87 | 5.56 | ||||
| PPARGC1B rs17572019 G>A | ||||||||
| GG | 435 | 87.53 | 698 | 89.26 | 1.00 | |||
| GA | 60 | 12.07 | 80 | 10.23 | 1.19(0.83-1.70) | 0.338 | 1.19(0.83-1.71) | 0.338 |
| AA | 2 | 0.40 | 4 | 0.51 | 0.79(0.15-4.35) | 0.790 | 0.81(0.14-4.52) | 0.808 |
| GA+AA | 62 | 12.47 | 84 | 10.74 | 1.18(0.84-1.68) | 0.343 | 1.19(0.83-1.69) | 0.341 |
| GG+GA | 495 | 99.60 | 778 | 99.49 | 1.00 | |||
| AA | 2 | 0.40 | 4 | 0.51 | 0.79(0.14-4.31) | 0.781 | 0.80(0.14-4.49) | 0.80 |
| A allele | 64 | 6.44 | 88 | 5.63 | ||||
a Adjusted for age, sex, smoking status, alcohol use and BMI status.
Bold values are statistically significant (P <0.05).