Table 2. Scoring system to evaluate systemic hypersensitivity reactions [56].

Score	Symptoms
0	No symptoms;
1	Scratching and rubbing around the nose and head;
2	Puffiness around the eyes and mouth, diarrhea, polar erection, reduced activity, and/or decreased activity with increased respiratory rate;
3	Wheezing, labored respiration, and cyanosis around the mouth and the tail;
4	No activity after prodding or tremor and convulsion;
5	Death.

Symptom scoring was independently performed by two investigators in a blind method.