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. 2017 Apr 8;8(23):37394–37408. doi: 10.18632/oncotarget.16962

Figure 3. LSS-11 binds DNA in vitro and in cell by minor groove binding.

Figure 3

(A) Fluorescent microscopic photography showing cells stained by Hoechst33258 (blue), LSS-11 (green) or both. Please note the mutual exclusive distribution of Hoechst33258 and LSS-11 fluorescence in nucleus. (B) and (C) Competitive fluorescent spectra titration of LSS-11 to Hoechst33258 (B) or EB (C). (D) Agarose electrophoresis of pUC-19 plasmid incubated with indicated concentrations of LSS-11 and stained with EB, pUC-19 digested by endonuclease was employed as a positive control.