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. 2017 Mar 21;8(23):37448–37463. doi: 10.18632/oncotarget.16394

Figure 8. Inhibition of PDGFRα enhances the effect of NT21MP-reversed EMT and invasion in SKBR-3 PR cells.

Figure 8

(A), Western blot assays were used to detect signal pathway molecule expression. In each group, the cells were treated after SDF-1α treatment alone or combined with NT21MP or PDGFRα inhibitor or activator in SKBR-3 PR cells. (B), Western blotting analysis was performed to detect the expressions of EMT markers in SKBR-3 PR cells treated with PDGFRα inhibitor alone or combined with NT21MP. (C), Invasion assays were conducted in SKBR-3 PR cells treated with PDGFRα inhibitor alone or combined with NT21MP. (D), Western blotting analysis was performed to detect the expression of PDGFRα in SKBR-3 PR cells treated with PDGFRα siRNA. BC: blank control siRNA; NC: negative siRNA; PS1-3: PDGFRα siRNA 1-3. (E), Western blotting analysis was performed to detect the expression of EMT markers in SKBR-3 PR cells treated with PDGFRα siRNA alone or combined with NT21MP.