Table 2. Sensitivities and specificities of single serodiagnostic markers in differentiating active TB (n=21) from LTBI (n=21) and ORD (n=42).
| Antigen | Ig class | AUC | TB vs ORD | AUC | TB vs LTBI |
|---|---|---|---|---|---|
| (95% CI) | Sensitivity/specificity (%) | (95% CI) | Sensitivity/specificity (%) | ||
| AlaDH | A | 0.73(0.59-0.86) | 0.76/0.69 | 0.73(0.57-0.89) | 0.76/0.71 |
| AlaDH | G | 0.63(0.49-0.76) | 0.62/0.64 | 0.65(0.47-0.83) | 0.76/0.57 |
| ESAT-6 | A | 0.73(0.60-0.86) | 0.67/0.79 | 0.75(0.61-0.89) | 0.67/0.81 |
| ESAT-6 | G | 0.46(0.27-0.65) | 0.52/0.60 | 0.45(0.25-0.64) | 0.52/0.52 |
| LAM | A | 0.64(0.49-0.79) | 0.52-0.76 | 0.59(0.41-0.76) | 0.52/0.76 |
| LAM | G | 0.91(0.83-0.98) | 0.86/0.90 | 0.95(0.89-1.00) | 0.86/0.95 |
| MPT64 | A | 0.96(0.92-1.00) | 0.95/0.90 | 0.97(0.91-1.00) | 0.95/0.90 |
| MPT64 | G | 0.69(0.56-0.82) | 0.76/0.60 | 0.71(0.54-0.88) | 0.76/0.67 |
| PstS1 | G | 0.43(0.28-0.58) | 0.52/0.52 | 0.51(0.32-0.70) | 0.62/0.62 |
| TB-LTBI | A | 0.76(0.63-0.88) | 0.67/0.76 | 0.76(0.61-0.91) | 0.67/0.86 |
| TB-LTBI | G | 0.90(0.83-0.98) | 0.90/0.79 | 0.89(0.78-0.99) | 0.90/0.71 |
| Tpx | G | 0.54(0.39-0.68) | 0.55/0.57 | 0.52(0.34-0.70) | 0.57/0.52 |
| TUB | A | 0.74(0.62-0.87) | 0.81/0.60 | 0.79(0.65-0.92) | 0.81/0.62 |
| 16kDa | A | 0.93(0.87-0.99) | 0.90/0.90 | 0.99(0.98-1.00) | 0.95/0.95 |
| 16kDa | G | 0.77(0.66-0.89) | 0.81/0.67 | 0.78(0.63-0.93) | 0.95/0.62 |
| 16kDa | M | 0.84(0.74-0.94) | 0.71/0.86 | 0.80(0.67-0.94) | 0.71/0.81 |
| 19kDa | A | 0.60(0.49-0.72) | 0.33/0.88 | 0.61(0.49-0.73) | 0.33/0.90 |
| 19kDa | G | 0.76(0.63-0.88) | 0.86/0.67 | 0.74(0.58-0.90) | 0.86/0.67 |
Receiver operator curve (ROC) analysis was used in determining the accuracy (sensitivity/specificity) of each serodiagnostic marker. ORD individuals comprised 21 LTBI and 21 QFT-ve ORD. Abbreviations: Ig = Immunoglobin; vs = versus; AUC = Area under the curve; CI = Confidence Interval.