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. 2017 Mar 25;8(23):37538–37549. doi: 10.18632/oncotarget.16556

Figure 3. Metformin inhibited GH secretion by GH3 cells.

Figure 3

(A) GH3 cells were incubated with different concentrations of metformin for 0, 12, 24, 36, 48, 60 and 72 h, and GH secretion was detected by ELISA. (B) GH3 cells were pretreated with or without compound C and then treated with metformin. p-AMPK(Thr172) and p-STAT3(Tyr705) were examined by Western blot. *P < 0.05; **P < 0.01.