Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 17;8(23):37717–37729. doi: 10.18632/oncotarget.17145

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2017 Tong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

(A) The genome-wide gene expression affected by KCTD11 overexpression in an Affymetrix Human U133 plus 2.0 array. (Fold change > 2.0 and p < 0.05) (B) Gene Ontology analysis of the genes regulated by KCTD11 overexpression. (C) After KCTD11 up-regulated, the expressions of CLDN1, CTGF, COL3A1, ATP2A2 and CD24 are detected by western blot. Beta-actin is used as a loading control. (D) Overexpression of KCTD11 inhibits cell adhesion in Huh7 and HCCLM3. Data is from three independent experiments and expressed as mean ± SD. *P<0.05. (E) Predicted protein bindings involving protein CTGF. (F) Co-immunoprecipitation assay confirms the protein binding between CTGF and COL3A1. (G) Knockdown of CTGF results in up-regulating of COL3A1 in western blot assay. Beta-actin is used as a loading control.