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. 2017 Apr 17;8(23):37717–37729. doi: 10.18632/oncotarget.17145

Figure 5. KCTD11 inhibits cell migration and invasion in HCC in vitro and inhibits tumor metastasis in vivo, by repressing MMPs and EMT.

Figure 5

(A) KCTD11 knock-down promotes cell migration and invasion in Huh7. KCTD11 overexpression inhibits cell migration and invasion in HCCLM3. Representative images are shown. Data is from three independent experiments and expressed as mean ± SD. (B) Nude mice liver orthotopic tumorigenesis experiment to evaluate lung metastasis. Representative images of the livers and lungs are shown. The tumor metastasis in lung is marked by arrows. (C) KCTD11 overexpression inhibits lung metastasis of HCC. The tumor clusters in lung are marked by arrows. Data are expressed as mean ± SD. (D) Expressions of Flag, MMP-2, MMP-9, Slug, Snail, E-cadherin, N-cadherin and Vimentin are detected by western blot. GAPDH is used as a loading control. *P<0.05, **P<0.01, ***P<0.001.