Table 1. BCH-2003 and CCLG-2008 treatment protocol.

	Stratification Criteria	Treatment Block
		Remission induction	Early intensification	Consolidation	Delay Intensification I	Maintenance I	Delay intensification II	Maintenance II
BCH-2003
SR	1 ≤ age < 6 WBC < 20 × 109/L Good prednisone response No T-cell and not mature B-cell No t(9;22) or MLL rearrangements Bone marrow morphology was M1 at day 33	VDLP (DNR×2)	CAM	HDMTX 3g/m2×4	VDLD+CAM	6-MP+MTX/VD+IT	HDMTX	6-MP+MTX/VD+IT
IR	Good prednisone response No t(9;22) Bone marrow morphology was M1 at day 33 Any one of : Age ≥ 6 or < 1 WBC ≥ 20 × 109/L T-cell MLL rearrangement	VDLP (DNR×4)	CAM×2	HDMTX 5g/m2×4	VDLD+CAM	6-MP+MTX/VD+IT	VDLA+VM26+ HD-Ara-c	6-MP+MTX/VD+IT
CCLG-2008	1 ≤ age < 10 WBC < 50 × 109/L Good prednisone response No T-cell and not mature B-cell
SR	No t(9;22), t(1;19) or MLL rearrangements Bone marrow morphology was M1/M2 at day 15 and M1 at day33 No CNSL MRD < 10–4 at day 33	VDLP (DNR×2)	CAM	HDMTX 2g/m2×4	VDLD+CAM	/	/	6-MP+MTX/VD+IT
IR	Good prednisone response No t(9;22) or MLL rearrangements Bone marrow morphology at day 15 was M1/M2 with IR protocol or M3 with SR protocol MRD < 10–2 at day 33 and < 10–3 at day 78 Any one of : Age ≥ 10 or < 1 WBC ≥ 50 × 109/L T-cell CNSL with no other high risk factor	VDLP (DNR×4)	CAM×2	HDMTX 5g/m2×4	VDLD+CAM	6-MP+MTX	VDLD+CAM	6-MP+MTX/VD+IT

WBC: white blood cell; SR: standard risk; IR: Intermediate-risk. MRD: minimal residual disease. CNSL: central nervous system leukemia.