Table 5. Multivariate Cox regression analysis for EFS.
| HR | 95% CI | P | |
|---|---|---|---|
| Immunophenotype | |||
| B-ALL | 1 | Reference | 0.870 |
| T-ALL | 1.094 | 0.371–3.230 | |
| WBC | |||
| < 50 × 109 | 1 | Reference | 0.059 |
| ≥ 50 × 109 | 2.385 | 0.968–5.877 | |
| TEL-AML1 | |||
| Negative | 1 | Reference | 0.935 |
| Positive | 0.959 | 0.344–2.668 | |
| MRD at day 33 | |||
| < 10–4 | 1 | Reference | 0.002 |
| ≥ 10–4 | 3.458 | 1.598–7.483 | |
| MRD at day 78 | |||
| < 10–3 | 1 | Reference | 0.001 |
| ≥ 10–3 | 6.330 | 2.181–18.369 | |
| SLCO1B1 rs4149056 | |||
| TT+TC | 1 | Reference | < 0.001 |
| CC | 12.242 | 3.937–38.059 | |
| SLC19A1 rs2838958 | |||
| AG+GG | 1 | Reference | 0.019 |
| AA | 2.324 | 1.147–4.710 |
EFS: event-free survival; WBC: white blood cell; MRD: minimal residual disease; HR: hazard ratio; CI: confidence interval.