Table 4. Univariate and multivariate analyses of various factors for PFS and OS.
No. of patients | PFS | OS | |||||||
---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | ||
Age, years (continuous) | 158 | 1.016 (0.994-1.039) | 0.154 | 1.043 (1.013-1.075) | 0.005 | 1.044 (1.014-1.075) | 0.004 | ||
Histology | |||||||||
Non-serous | 28 | 1 (Reference) | 1 (Reference) | ||||||
Serous | 124 | 1.226 (0.611-2.462) | 0.567 | 1.072 (0.454-2.530) | 0.874 | ||||
Tumor grade | |||||||||
Grade 1 | 7 | 1 (Reference) | 1 (Reference) | ||||||
Grade 2-3 | 151 | 1.364 (0.576-3.186) | 0.227 | 1.140 (0.345-3.765) | 0.83 | ||||
Preoperative CA 125, U/ml | |||||||||
≤500 | 58 | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||||
>500 | 94 | 1.722 (1.030-2.881) | 0.038 | 1.713 (1.053-2.789) | 0.033 | 1.540 (0.782-3.033) | 0.212 | ||
Suspected LN metastasis on preoperative imaging studies | |||||||||
No | 69 | 1 (Reference) | 1 (Reference) | ||||||
Yes | 83 | 1.326 (0.809-2.171) | 0.263 | 1.461 (0.746-2.860) | 0.269 | ||||
LN metastasis | |||||||||
No | 55 | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||||
Yes | 103 | 2.060 (1.162-3.651) | 0.013 | 2.238 (1.304-3.841) | 0.004 | 1.331 (0.628-2.820) | 0.455 | ||
Residual disease | |||||||||
NGR | 39 | 1 (Reference) | 1 (Reference) | ||||||
R < 1 cm | 113 | 1.102 (0.604-2.011) | 0.752 | 1.251 (0.498-3.142) | 0.634 | ||||
Lymphadenectomy | |||||||||
LNS | 58 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
LND | 94 | 0.613 (0.384-0.979) | 0.041 | 0.629 (0.400-0.989) | 0.048 | 0.310 (0.163-0.588) | <0.001 | 0.250 (0.137-0.456) | <0.001 |
PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; CA 125, cancer antigen 125; NGR, no gross residual disease; R, residual disease; LNS, lymph node sampling; LND, lymph node dissection