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. 2017 Mar 31;8(23):38044–38055. doi: 10.18632/oncotarget.16765

Figure 2. EZH2 regulation and function in prostate cancer.

Figure 2

EZH2 is the enzymatic subunit of PRC2, which catalyzes H3K23me3. EZH2 induces transcriptional silencing of tumor suppressor genes, which subsequently cause tumor initiation, growth and progression. EZH2 is regulated by E2F, p53, MYC, AKT, miR101, miR26a, miR26b and Let-7.