Table 1. List of downstream targets of EZH2 in urological cancer.

Cancer type	Target genes	Function	Contribution to tumorigenesis	Reference
Prostate	MSMB	Inhibits MMP secretion	Proliferation and invasion	83
	DAB2IP	Inhibition of NF-kB/Ras pathway	Transformation, proliferation and invasion	75, 76
	E-cadherin	maintain epithelial cellular adhesion	invasion	92
	ADRB2	B-adrenergic signaling	Transformation and invasion	77
	SLIT2	Chemorepellent protein	Proliferation and invasion	79
	TIMP2/3	ECM degradation	Invasion	82
	PCAT-1	Transcriptional repressor lincRNA	Proliferation	84
	RKIP	Inhibition of Raf and NF-kB pathways	Invasion	85
Bladder	APAF-1	apoptosis promoting factor	Proliferation and invasion	91
	E-cadherin	maintain epithelial cellular adhesion	Invasion	92
Kidney	E-cadherin	maintain epithelial cellular adhesion	Invasion	53