Table 4. . Adjusted linear regression estimates† (β-values and 95% CIs) per decile of the respective indices, or individual bacterium or cytokine expression with gestational age at delivery.
| WQS indices | β-value (95% CI) | p-value |
|---|---|---|
| WQS bacterial index |
-0.23 (-0.40 to -0.083) |
0.002 |
| WQS cytokine index |
-0.24 (-0.40 to -0.084) |
0.003 |
|
Bacterial species/genus | ||
|
Bacteroides |
-0.05 (-0.11–0.008) |
0.09 |
|
Gardnerella vaginalis |
-0.05 (-0.10 to -0.002) |
0.04 |
|
Mobiluncus |
-0.03 (-0.08–0.03) |
0.4 |
|
Mycoplasma |
-0.12 (-0.40–0.15) |
0.4 |
|
Ureaplasma urealyticum |
-0.07 (-0.12 to -0.02) |
0.004 |
|
Cytokine | ||
|
IL-2 |
-0.26 (-0.63–0.12) |
0.18 |
|
IL-6 |
-0.14 (-0.26 to -0.03) |
0.01 |
|
IL-8 |
-0.20 (-0.32 to -0.08) |
0.001 |
| TNF | -0.15 (-0.27–0.03) | 0.01 |
†βs derived from the individual regressions represent shorter gestation per log2 expression of 16S bacterial rRNA or cytokine mRNA whereas βs in the regressions using the WQS indices are per decile of the index.
WQS: Weighted quantile sum.