Table 2. Detailed analyses of candidate immune markers: correlations with clinical risk factors and physical frailty components.

	Clinical risk factors Frailty components	CD4/CD8 ratio		CD4 + CD28 − CD27 +		CD8 + CD28 − CD27 +		CD8 + CD28 −
		Rho	P-value	Rho	P-value	Rho	P-value	Rho	P-value
Zero order correlations	Female sex	0.038	0.430	0.002	0.970	0.020	0.680	0.005	0.92
	Age	−0.065	0.181	−0.055	0.260	0.037	0.440	0.167	0.001
	No. of medical morbidities	−0.025	0.610	−0.102	0.037	−0.018	0.710	0.063	0.194
	Frailty score	0.112	0.021	0.098	0.044	0.128	0.008	0.116	0.017
	BMI	0.122	0.012	−0.036	0.457	−0.029	0.560	−0.096	0.05
	6-m fast gait, s	0.113	0.021	0.054	0.270	0.110	0.024	0.061	0.215
	Energy	−0.004	0.930	0.002	0.960	−0.032	0.520	−0.057	0.244
	Physical activity score	0.076	0.121	0.025	0.610	−0.062	0.204	−0.051	0.297
	Knee extension strength	−0.061	0.213	−0.112	0.021	−0.141	0.004	−0.208	0.001
Partial correlations controlling for age, sex and number of comorbidities	Frailty score	0.139	0.004	0.094	0.055	0.147	0.003	0.086	0.080
	BMI	0.145	0.003	−0.035	0.474	−0.056	0.250	−0.091	0.060
	6-m fast gait, s	0.147	0.003	0.026	0.590	0.092	0.060	0.043	0.390
	Energy	−0.008	0.870	0.015	0.760	−0.048	0.330	−0.054	0.270
	Physical activity score	0.056	0.250	−0.002	0.960	−0.116	0.018	−0.042	0.390
	Knee extension strength	−0.120	0.014	−0.129	0.008	−0.156	0.001	−0.148	0.002

Abbreviation: BMI, body mass index.