Table 3. Ordinal logistic regression odds ratio of association of T-cell subsets with frailty status (robust, prefrail and frail).
| T-cell subset markers |
Unadjusted
|
Adjusted for age, sex and multimorbidity
|
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| CD4/CD8 ratio (tertile score: 1,2,3) | 1.18 | 0.96–1.45 | 0.108 | 1.27 | 1.03–1.57 | 0.026 |
| Low tertile | 1 | 1 | ||||
| Mid tertile | 1.06 | 0.61–1.84 | 0.84 | 1.09 | 0.62–1.93 | 0.75 |
| High tertile | 1.41 | 0.93–2.12 | 0.102 | 1.63 | 1.07–2.48 | 0.023 |
| CD4/CD8<1.0 (binary: 0,1) | 0.71 | 0.36–1.42 | 0.33 | 0.84 | 0.42–1.71 | 0.64 |
| CD4+CD28−CD27+ (tertile scores: 1,2,3) | 1.25 | 1.00–1.55 | 0.049 | 1.29 | 1.03–1.62 | 0.025 |
| Low tertile | 1 | 1 | ||||
| Mid tertile | 1.45 | 0.91–2.29 | 0.115 | 1.65 | 1.03–2.64 | 0.037 |
| High tertile | 1.55 | 1.00–2.41 | 0.052 | 1.66 | 1.06–2.61 | 0.027 |
| CD8+CD28−CD27+ (tertile scores:1,2,3) | 1.35 | 1.07–1.70 | 0.012 | 1.35 | 1.06–1.71 | 0.013 |
| Low tertile | 1 | 1 | ||||
| Mid tertile | 0.80 | 0.50–1.26 | 0.33 | 0.84 | 0.53–1.34 | 0.47 |
| High tertile | 1.81 | 1.14–2.88 | 0.012 | 1.80 | 1.13–2.89 | 0.014 |
| CD8+CD28− (tertile scores: 1,2,3) | 1.42 | 1.13–1.78 | 0.002 | 1.31 | 1.04–1.66 | 0.022 |
| Low tertile | 1 | 1 | ||||
| Mid tertile | 1.44 | 0.91–2.30 | 0.123 | 1.28 | 0.80–2.06 | 0.30 |
| High tertile | 2.01 | 1.28–3.17 | 0.002 | 1.72 | 1.08–2.74 | 0.022 |
Abbreviations: CI, confidence interval; OR, odds ratio.
Ordinal logistic regression models were fitted with Frailty status (0, 1–2, 3–5) as the ordinal dependent variable and tertile categories of immune biomarker as the independent variable was used as a ranked score independent variable. Age, sex and number of comorbidities were included as fixed covariates in the models.