Table 1. Gene expression of cytokines and chemokines.
| Name | Functions in inflammation |
Ratio versus controla |
||
|---|---|---|---|---|
| D1 | D2 | D3 | ||
| CCL2 | Chemokine, recruits monocytes | 3.3 | 41 | 24 |
| CXCL1 | Cytokine, neutrophil chemoattractant | 2.4 | 7.6 | 7.2 |
| CXCL2 | Cytokine, chemotactic to leukocytes | 2.7 | 3.4 | 5.1 |
| CXCL3 | Cytokine, monocyte migration | 1.8 | 4.2 | 6.0 |
| IL-1-beta | Cytokine, induces COX-2, inflammation | 1.8 | 5.1 | 4.4 |
| Interferon-gamma | Cytokine, activates macrophages | 1 | 1.2 | 7.2 |
| TNF-alpha | Cytokine, stimulates acute phase reaction | 3.3 | 5.1 | 3.2 |
| iNOS | Inducible production of nitric oxide | 1.1 | 2.4 | 8.6 |
| TRL-6 | Proinflammatory receptor | 1 | 1.9 | 3.0 |
| Fos | Transcription factor | 1.1 | 3.8 | 4.1 |
| Jun | Transcription factor | 1.1 | 4.2 | 4.6 |
| IL8 | Chemokine, recruits neutrophils | 5.0 | 35 | 58 |
| IL8b | Secreted protein | ND | 50b | 139b |
a
Days 1, 2, and 3 following the induction of Aβ synthesis in MC65 human nerve cells. Ratio of induced to uninduced. Done by Nano-String. Twelve of 184 genes assayed.
b
Secreted IL8 pg/ml/106 cells.