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. 2016 Aug 18;2:16017. doi: 10.1038/npjamd.2016.17

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Copyright © 2016 Published in partnership with the Japanese Society of Anti-Aging Medicine

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Regulation of the functional connection between NAD⁺ and sirtuins. There are at least three levels of regulation: (1) regulation of NAD⁺ biosynthesis, particularly mediated by NAMPT, (2) modulation of sirtuin activity, including inhibition by nicotinamide and NADH and activation of SIRT6 by long-chain fatty acids, and (3) competition with other NAD⁺-consuming enzymes, such as PARPs and CD38/157 ectoenzymes. See details in text. NAD⁺, nicotinamide adenine dinucleotide; NAMPT, nicotinamide phosphoribosyltransferase; PARPs, poly-ADP-ribose polymerases.