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. 2016 Oct 13;2:16022. doi: 10.1038/npjamd.2016.22

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Increased fatty acid oxidation (FAO) is a general response to acute genotoxic stress. (a) Cumulative FAO of tritiated palmitate of a representative control mouse dermal fibroblast (MDF) line (Rep Cont MDF) over the indicated time period after exposure to 0 or 20 J/m² UV-C; Student’s t-test between treatment groups within time point. (b) Cumulative FAO of tritiated palmitate of two additional UV-C treated control MDF lines expressed relative to untreated at the indicated time point post-irradiation, and of 3 UV-C treated WT human diploid fibroblast (HDF) lines relative to untreated at the indicated time; Student’s t-test. (c) messenger RNA (mRNA) expression of FAO-related genes in control MDFs 6 h after exposure to 20 J/m² UV-C expressed relative to mock irradiated cells; Student’s t-test. (d) Cumulative FAO of tritiated palmitate of three independent MDF and HDF lines exposed to 40 μ mol/l mitomycin C (MMC) expressed relative to untreated at the indicated time point; Student’s t-test. (e,f) Gene expression of FAO-related genes (e) and FAO capacity (f) in liver from 8 week WT mice injected intraperitoneally (IP) with 10 mg/kg MMC or saline and harvested after 24 h (n=4/group); Student’s t-test between treatment groups. (g) FAO capacity of liver from 8 week WT mice injected IP with 100 or 200 mg/kg irinotecan or saline and harvested after 24 h (n=4/group); Student’s t-test. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.