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. 2016 Nov 10;2:16026. doi: 10.1038/npjamd.2016.26

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Metformin improves premature osteogenic differentiation of HGPS MSCs. (a) Measure of alkaline phosphatase activity in osteogenic progenitors derived from HGPS MSCs (HGPS OP) treated with 5 mmol/l metformin or 1 μmol/l tipifarnib (FTI). (b) Quantification of alkaline phosphatase activity in HGPS OP treated with 5 mmol/l metformin or 1 μmol/l tipifarnib (FTI). Statistical analysis was performed by one-way analysis of variance (ANOVA), using Dunnett’s comparison test. Values of P<0.05 were considered significant (***P<0.001). HGPS, Hutchinson–Gilford progeria syndrome; FTI, farnesyl transferase inhibitor; Met, metformin; MSC, mesenchymal stem cell.