Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 28;2:16018. doi: 10.1038/npjamd.2016.18

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Published in partnership with the Japanese Society of Anti-Aging Medicine

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Role of macrophages in the clearance of senescent cells. Senescent cells secrete proinflammatory mediators, senescence-associated secretory phenotype (SASP) factors. SASP factors recruit immune cells (macrophages, neutrophils and T cells), which then clear the senescent cells. In addition, CD4⁺ T cells are known to survey the antigens expressed in premalignant senescent hepatocytes and interact with monocytes/macrophages to clear those senescent cells.¹¹⁵ Note that the biological effects of SASP factors are not limited to the recruitment of immune cells. SASP factors may promote cell proliferation, differentiation and migration as well as extracellular matrix remodeling. Consequently, SASP factors likely contribute to tissue regeneration and healing. However, they may also promote inflammation in age-associated pathologies.