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. 2016 Nov 24;2:16029. doi: 10.1038/npjamd.2016.29

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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The mRNA expression levels of SIRT1, hTERT, CD105, ATM, ATR, BRCA1, Chk1, OTUB1, p53, CASP3, CtIP, Rad50, Rad51, Rad52, c-Abl, and FANCD2 in NHDF cells, scramble/NHDF cells or 520d-5p/NHDF cells. The expression of twelve representative genes is shown. Transfection by 520d-5p after irradiation induced the downregulation of SIRT1, CD105, ATM and CASP3; however, CD105 was upregulated in viable cells a month after transfection. p53 tended to be transiently upregulated but decreased during senescence. hTERT levels were not affected by 520d-5p. OTUB1, Chk1, c-Abl and p53 maintained or upregulated the expression levels initially after transfection by 520d-5p, followed by ATR, BRCA1, CD105, SIRT1 and hTERT upregulation. hTERT, human telomerase reverse transcriptase.