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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: J Am Chem Soc. 2016 Feb 8;138(6):1800–1803. doi: 10.1021/jacs.5b12648

Figure 4.

Figure 4

Type II photosensitization cross-linking of Ras. Proposed mechanism of nonspecific cross-linking reaction involves the dye photosensitizer cycling between the ground (S0) and triplet states (T*). The energy transfers to molecular oxygen (O2), which becomes excited to the singlet state (1O2). This ROS reacts with Ras, which forms a free radical species and cross-links with another Ras.