Table 3.
Unadjusted Data: Protein Levels in Plasma, Relative mRNA Expression in Peripheral Blood, and mRNA Expression in the Dorsolateral Prefrontal Cortex
| Parameters | Schizophrenia | Bipolar Disorder | Healthy Controls | |||
|---|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | N | Median (IQR) | |
| Plasma cytokine/protein | ||||||
| TNF (pg/mL) | 352 | 1.20 (1.28) | 168 | 1.16 (1.04) | 358 | 1.09 (1.03) |
| sTNFR1 (ng/mL) | 569 | 1.76 (0.74) | 247 | 1.67 (0.52) | 624 | 1.60 (0.77) |
| sTNFR2 (ng/mL) | 553 | 4.76 (1.43) | 239 | 4.60 (1.47) | 591 | 4.51 (1.44) |
| ADAM17 (pg/mL) | 548 | 189 (282) | 240 | 227 (358) | 594 | 214 (341) |
| Leukocyte mRNA | ||||||
| TNF mRNA | 224 | 0.89 (0.44) | 142 | 0.92 (0.41) | 184 | 1.00 (0.58) |
| TNFR1 mRNA | 224 | 1.02 (0.32) | 143 | 1.08 (0.46) | 184 | 1.00 (0.31) |
| TNFR2 mRNA | 224 | 0.98 (0.36) | 143 | 1.00 (0.46) | 184 | 1.00 (0.43) |
| ADAM17 mRNA | 224 | 1.02 (0.29) | 142 | 1.24 (0.46) | 184 | 1.00 (0.38) |
| DLPFC mRNA | ||||||
| TNF mRNA | 80 | 0.03 (0.05) | 44 | 0.03 (0.06) | 86 | 0.02 (0.05) |
| TNFR1 mRNA | 80 | 3.87 (3.10) | 44 | 3.19 (2.43) | 86 | 2.35 (0.77) |
| TNFR2 mRNA | 80 | 1.74 (1.20) | 44 | 1.37 (0.63) | 86 | 1.44 (0.64) |
| ADAM17 mRNA | 80 | 3.25 (0.95) | 44 | 2.83 (0.91) | 86 | 3.40 (0.94) |
Note: TNF, tumor necrosis factor; sTNFR1, soluble TNF receptor 1; sTNFR2, soluble TNF receptor 2; ADAM17, a disintegrin and metalloprotease-17 protein; DLPFC, dorsolateral prefrontal cortex; IQR, interquartile range.
Data are given as median with interquartile range due to skewed distributions.