Table 3.
Comparison between HCC versus no-HCC in Non-T2DM patients.
| Variables | HCC (n=42) | Non-HCC (n=49) | P value | ||||
|---|---|---|---|---|---|---|---|
| No. Pts available | Mean±SD or frequency (percentage) | Median (range) | No. Pts available | Mean±SD or frequency (percentage) | Median (range) | ||
| Sex (male/female), n (%) | 42 | 37 (88.1%)/ 5 (11.9%) | 49 | 35 (71.4%)/ 14 (28.6%) | 0.070 | ||
| Age (years) | 42 | 57.49±7.09 | 57.46 (40.08–69.33) | 49 | 56.02±8.09 | 56.05 (42.49–79.61) | 0.365 |
| Ascites, n (%) | 42 | 49 | 0.729 | ||||
| No | 21 (50%) | 25 (51%) | |||||
| Mild | 4 (9.5%) | 7 (14.3%) | |||||
| Moderate to severe | 17 (40.5%) | 17 (34.7%) | |||||
| HE, n (%) | 42 | 49 | 0.684 | ||||
| No | 40 (95.2%) | 45 (91.8%) | |||||
| Grade I–II | 1 (2.4%) | 3 (6.1%) | |||||
| Grade III–IV | 1 (2.4%) | 1 (2%) | |||||
| Laboratory tests | |||||||
| RBC (1012/L) | 42 | 3.49±0.90 | 3.51 (1.63–5.65) | 49 | 3.16±0.82 | 2.98 (1.55–5.19) | 0.068 |
| Hb (g/L) | 42 | 106.31±32.8 | 111.5 (3.2–160) | 49 | 95.16±29.67 | 91 (37–165) | 0.092 |
| WBC (109/L) | 42 | 6.06±4.94 | 4.4 (1.1–30.7) | 49 | 4.34±3.20 | 3.8 (0.9–19.6) | 0.05 |
| PLT (109/L) | 42 | 111.57±79.37 | 95 (22–392) | 49 | 83.16±41.12 | 77 (18–196) | 0.041 |
| TBIL (umol/L) | 42 | 44.71±58.11 | 26.05 (7.5–241.4) | 49 | 31.32±53.74 | 20.4 (4.7–374.9) | 0.257 |
| ALB (g/L) | 42 | 33.49±6.43 | 33.25 (20.1–53.9) | 49 | 31.90±5.85 | 33.2 (17.3–41.7) | 0.22 |
| ALT (U/L) | 42 | 79.45±138.82 | 39.5 (9–827) | 49 | 32.08±20.30 | 26 (9–113) | 0.034 |
| AST (U/L) | 42 | 136.19±248.44 | 54.5 (17–1318) | 49 | 46.61±46.70 | 33 (11–305) | 0.026 |
| ALP (U/L) | 42 | 123.40±65.62 | 109 (46–392) | 49 | 79.31±32.24 | 71.1 (39.3–174) | <0.001 |
| GGT (U/L) | 42 | 161.69±173.07 | 116 (24–994) | 48 | 47.73±40.08 | 30.5 (8–205) | <0.001 |
| BUN (mmol/L) | 42 | 7.15±8.04 | 5.15 (1.54–55.01) | 49 | 7.13±5.41 | 5.97 (2.1–37.54) | 0.991 |
| Cr (umol/L) | 42 | 65.05±31.64 | 59.65 (33–221) | 49 | 81.73±104.99 | 55 (28–675) | 0.295 |
| K (mmol/L) | 42 | 4.11±0.54 | 3.96 (3.26–5.8) | 49 | 3.97±0.41 | 4 (2.9–5.21) | 0.168 |
| Na (mmol/L) | 42 | 137.68±5.57 | 138.6 (109.2–143.7) | 49 | 138.51±3.96 | 139 (130.4–148.5) | 0.409 |
| Ca (mmol/L) | 13 | 2.17±0.22 | 2.13 (1.89–2.76) | 21 | 2.02±0.22 | 2.06 (1.35–2.41) | 0.086 |
| PT (second) | 42 | 15.76±4.41 | 14.5 (11–40.9) | 49 | 16.47±3.33 | 15.3 (11.8–27.5) | 0.385 |
| APTT (second) | 42 | 41.04±7.40 | 39.4 (28.2–61.7) | 49 | 44.39±8.63 | 44 (29.7–74.6) | 0.052 |
| INR | 42 | 1.28±0.50 | 1.16 (0.81–4.19) | 49 | 1.35±0.36 | 1.23 (0.86–2.53) | 0.439 |
| Titer of HBV-DNA (104 copies/ml) | 16 | 92.22±149.28 | 10.5 (1–470) | 17 | 1957.08±5884.11 | 58 (0.11–24000) | 0.210 |
| Child-Pugh class, n (%) | 42 | 49 | 0.551 | ||||
| A | 19 (45.2%) | 21 (42.9%) | |||||
| B | 20 (47.6%) | 21 (42.9%) | |||||
| C | 3 (7.1%) | 7 (14.3%) | |||||
| Child-Pugh score | 42 | 7.24±1.95 | 7 (5–14) | 49 | 7.25±2.02 | 7 (5–12) | 0.987 |
| MELD score | 42 | 5.80±5.63 | 4.23 (−3.39–19.63) | 49 | 6.66±7.29 | 4.39 (−2.57–37.57) | 0.536 |
ALB – albumin; ALP – alkaline phosphatase; ALT – alanine aminotransferase; APTT – activated partial thromboplastin time; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium ion; Cr – creatinine; GGT – γ-glutamine transferase; HE – hepatic encephalopathy; HCC – hepatocellular carcinoma; Hb – hemoglobin; INR – international normalized ratio; K – potassium ion; MELD – model for end-stage liver disease; Na – sodium ion; NA – not available; PLT – platelet; PT – prothrombin time; Pts – patients; RBC – red blood cell; T2DM – type 2 diabetes; TBIL – total bilirubin; WBC – white blood cell.