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Loss of mitofilin results in drastically altered mitochondrial ultrastructure. Electron microscopic images of the control (A and D) versus mitofilin (B and C, E and F) siRNA-treated HeLa cells showing mitochondrial ultrastructures after the first round (A–C) and the second round (D–F) of transfection. Arrows indicate the multiple concentric sheets of the inner membrane. Bar, 250 nm.
