Figure 4. Albumin expression in murine retinas.

Albumin content was higher in the retinas of db/db mice when compared with non-diabetic littermates. Systematical administration of fluorofenidone significantly decreased extravascular leakage of albumin in db/db mice. The difference between placebo-treated db/db mice and db/db mice treated with fluorofenidone was statistically significant (^aP<0.05). The difference between placebo-treated db/db mice and normal control mice was statistically significant (^cP<0.05).