Figure 5. Effects of MAPK and NF-κB inhibitors on UVB-induced secretion of IL-6 and IL-8 by corneal limbus epithelial cells.

A: Various signal pathway inhibitors, including SP600125, JNK inhibitor (JNK); SB203580, p38 MAPK inhibitor (p38) and BAY11-7082, NF-κB inhibitor (NF-κB) significantly decreased the UVB-induced secretion of IL-6 by cultured limbus epithelial cells; B: The secretion of IL-8 was measured after the same management in (A). Error bars reveal the means±standard deviation in triplicate tests. ^aP<0.05 as compared with cells irradiated with UVB alone.