Table 3.
Cox regression analysis of 1-year and long-term mortality
| Univariate HR (95% CI) | p Value | 1-Year mortality Multivariable HR (95% CI) |
p Value | Long-term mortality Multivariable HR (95% CI) |
p Value | |
| Age (per 1-year increase) | 1.12 (0.97 to 1.29) | 0.132 | 1.01 (0.98 to 1.03) | 0.497 | 1.19 (1.01 to 1.41) | 0.038 |
| Persistent acute kidney injury | 2.12 (1.57 to 2.88) | <0.001 | 2.74 (1.80 to 4.16) | <0.001 | 2.04 (1.49 to 2.81) | <0.001 |
| eGFR (per 1 mL/min/1.73 m2 increase) | 0.93 (0.88 to 0.97) | 0.002 | 0.99 (0.99 to 1.00) | 0.102 | 0.94 (0.90 to 0.99) | 0.031 |
| Male | 1.42 (1.17 to 1.73) | <0.001 | 1.54 (1.09 to 2.18) | 0.015 | 1.50 (1.22 to 1.86) | <0.001 |
| NYHA I | Ref | – | – | – | – | – |
| NYHA II | 1.17 (0.16 to 8.68) | 0.878 | – | – | – | – |
| NYHA III | 1.30 (0.18 to 9.23) | 0.796 | – | – | – | – |
| NYHA IV | 1.93 (0.27 to 13.8) | 0.514 | – | – | – | – |
| LVEF >50% | Ref | Ref 1.0 | ||||
| LVEF 40%–49% | 1.47 (1.15 to 1.87) | 0.002 | 1.69 (1.13 to 2.53) | 0.011 | 1.36 (1.06 to 1.75) | 0.018 |
| LVEF 30%–39% | 1.43 (1.10 to 1.88) | 0.009 | 1.52 (0.97 to 2.38) | 0.070 | 1.33 (1.00 to 1.76) | 0.049 |
| LVEF <30% | 1.54 (1.09 to 2.19) | 0.014 | 1.99 (1.22 to 3.20) | 0.005 | 1.36 (0.96 to 1.94) | 0.088 |
| Prior stroke | 1.26 (0.98 to 1.62) | 0.073 | 1.14 (0.75 to 1.72) | 0.482 | 1.14 (0.87 to 1.48) | 0.341 |
| Known diabetes | 1.36 (1.09 to 1.69) | 0.007 | 1.47 (1.01 to 2.11) | 0.040 | 1.46 (1.15 to 1.85) | 0.002 |
| Known hypertension | 0.82 (0.67 to 1.01) | 0.069 | 0.71 (0.50 to 1.00) | 0.052 | 0.76 (0.61 to 0.95) | 0.014 |
| Prior cardiac surgery/prior PCI | 0.59 (0.42 to 0.82) | 0.002 | 0.66 (0.53 to 0.82) | <0.001 | ||
| Prior cardiac surgery | 0.70 (0.57 to 0.87) | 0.001 | – | – | – | – |
| Prior PCI | 0.94 (0.76 to 1.16) | 0.578 | – | – | – | – |
| Prior COPD | 1.28 (1.02 to 1.61) | 0.034 | 1.04 (0.71 to 1.52) | 0.842 | 1.18 (0.93 to 1.50) | 0.175 |
| Peripheral arterial disease | 1.22 (0.97 to 1.51) | 0.084 | 1.48 (1.02 to 2.16) | 0.041 | 1.24 (0.97 to 1.58) | 0.082 |
| Atrial fibrillation | 1.33 (1.09 to 1.62) | 0.004 | 1.39 (1.01 to 1.91) | 0.044 | 1.28 (1.05 to 1.57) | 0.016 |
| Logistic EuroSCORE I (n=1332) | 2.48 (1.21 to 5.07) | 0.013 | – | – | – | – |
| Prosthesis make | Ref (CoreValve) | Ref (CoreValve) | Ref (CoreValve) | |||
| Edwards | 0.92 (0.76 to 1.12) | 0.418 | 0.83 (0.60 to 1.15) | 0.276 | 0.90 (0.73 to 1.11) | 0.315 |
| Other | 0.54 (0.20 to 1.48) | 0.236 | 0.60 (0.22 to 1.65) | 0.322 | 0.59 (0.22 to 1.61) | 0.305 |
COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; PCI, percutaneous coronary intervention.