Table 2. Somatic mutations in known cancer genes.

Sample	Gene	Mutation	Frequency
1	EP300	p.G1777C	0.06
2	DNMT3A	p.Y533C	0.185
3	EZH2	p.A483S	0.46
	TP53	p.M169I	0.029
4	BCOR	p.P1156L	0.49
	EPHA7	p.G592S	0.14
	WT1	p.T278I	0.11
	TET2	p.Q1702*	0.06
	EGFR	p.A871E	0.042
5	ALK	p.R1209Q	0.21
	ETV6	p.P25S	0.038
6	NOTCH2	p.P1101T	0.18
	NF1	p.Q2434H	0.099
	SMARCA4	p.D694E	0.087
12	TET2	p.E1874K	0.17

Mutations listed in this table were identified by targeted sequencing with an allele frequency of ⩾10%. Mutations occurring at a lower frequency were included if previously reported in COSMIC.