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. 2015 Oct 21;1:15018. doi: 10.1038/npjbcancer.2015.18

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Copyright © 2015 Breast Cancer Research Foundation/Macmillan Publishers Limited

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Spatiotemporal progression diagram over a 10-year period of subsets of breast cancer patients. The innermost to outermost rings show progression patterns of primary breast cancer patients (pink ring) and formation of metastases (subsequent rings). Circular arc length of each sector represents the percentage of patients with a metastatic tumor in that location. Bone (yellow) is the most common first metastatic site (first ring outside pink). (a) All Patients, (b) ER+/HER2−, (c) ER−/HER2−, and (d) HER2+.