Table 1. Genes of Prevotella nigrescens differentially expressed in health and disease.
| Locus tag | Log2 fold change | Log2 CPM | P value | Gene product |
|---|---|---|---|---|
| pnig_c_8_1174 | 11.7 | 10.6 | 0.000 | Hypothetical protein |
| pnig_c_6_998 | 10.2 | 9.1 | 0.000 | d,d-heptose 1,7-bisphosphate phosphatase |
| pnig_c_6_996 | 10.2 | 9.0 | 0.000 | Dehydrogenase |
| pnig_c_6_999 | 9.9 | 8.8 | 0.000 | Hypothetical protein |
| pnig_c_26_1881 | 9.6 | 8.6 | 0.000 | DNA-binding protein |
| pnig_c_8_1173 | 9.4 | 8.5 | 0.000 | Hypothetical protein |
| pnig_c_1_3 | 9.1 | 8.2 | 0.003 | Peptidase M26 |
| pnig_c_6_997 | 8.8 | 7.9 | 0.000 | Phosphoheptose isomerase |
| pnig_c_6_1000 | 8.3 | 7.4 | 0.013 | Membrane protein |
| pnig_c_43_2127 | 7.9 | 7.3 | 0.044 | Transposase |
| pnig_c_45_2145 | 7.6 | 8.6 | 0.000 | Hypothetical protein |
| pnig_c_1_164 | 7.2 | 6.5 | 0.005 | Acyl-CoA synthetase |
| pnig_c_1_166 | 6.9 | 6.2 | 0.023 | Fumarate hydratase |
| pnig_c_53_2187 | 6.1 | 9.0 | 0.002 | ABC transporter ATP-binding protein |
| pnig_c_9_1255 | 5.9 | 7.7 | 0.001 | Porin |
| pnig_c_45_2144 | 5.5 | 7.3 | 0.006 | Membrane protein |
| pnig_c_4_784 | 5.2 | 6.4 | 0.037 | Endonuclease |
| pnig_c_6_1004 | 5.0 | 8.2 | 0.026 | Polysaccharide biosynthesis protein |
| pnig_c_6_1013 | 4.1 | 8.8 | 0.001 | NAD-utilising dehydrogenase |
| pnig_c_7_1093 | 4.0 | 8.9 | 0.000 | Phosphoglucomutase |
| pnig_c_25_1868 | 4.0 | 13.5 | 0.000 | |
| pnig_c_26_1883 | 3.5 | 9.7 | 0.002 | Haem ABC transporter ATP-binding protein |
| pnig_c_25_1874 | 3.5 | 7.8 | 0.026 | Dolichyl-phosphate beta-d-mannosyltransferase |
| pnig_c_6_1017 | 3.5 | 7.8 | 0.037 | Amidase |
| pnig_c_7_1096 | 3.4 | 9.7 | 0.000 | Cell division protein |
| pnig_c_2_296 | 3.4 | 9.5 | 0.001 | Hypothetical protein |
| pnig_c_9_1256 | 3.3 | 7.7 | 0.047 | l-asparaginase |
| pnig_c_4_675 | 3.2 | 8.8 | 0.012 | Peptidase M16 |
| pnig_c_4_751 | 3.1 | 10.4 | 0.000 | Molecular chaperone DnaJ |
| pnig_c_14_1504 | 3.1 | 9.2 | 0.047 | Surface protein |
| pnig_c_17_1619 | 3.0 | 9.3 | 0.003 | Membrane protein |
| pnig_c_7_1098 | 2.9 | 8.4 | 0.044 | Exodeoxyribonuclease III |
| pnig_c_7_1113 | 2.9 | 9.3 | 0.005 | Cfr family radical SAM enzyme |
| pnig_c_11_1323 | 2.8 | 9.2 | 0.012 | DNA topoisomerase IV subunit A |
| pnig_c_2_295 | 2.7 | 8.1 | 0.046 | Hypothetical protein |
| pnig_c_19_1677 | 2.7 | 9.5 | 0.004 | Cysteine desulfurase activator complex subunit SufB |
| pnig_c_26_1900 | 2.5 | 8.2 | 0.043 | Hypothetical protein |
| pnig_c_29_1964 | 2.4 | 8.8 | 0.043 | Multidrug transporter |
| pnig_c_4_746 | 2.4 | 9.6 | 0.044 | DNA-binding protein |
| pnig_c_4_804 | 2.4 | 9.4 | 0.011 | Phosphoribosylaminoimidazole-succinocarboxamide synthases |
| pnig_c_4_749 | 2.3 | 10.1 | 0.006 | ABC transporter ATP-binding protein |
| pnig_c_4_682 | 2.3 | 10.1 | 0.006 | Carbamoyl phosphate synthase large subunit |
| pnig_c_11_1334 | 2.3 | 9.6 | 0.023 | GTPase Era |
| pnig_c_5_926 | 2.2 | 10.0 | 0.048 | Imidazolonepropionase |
| pnig_c_30_1970 | 2.1 | 10.0 | 0.050 | Histidyl-tRNA synthase |
| pnig_c_11_1333 | 2.1 | 11.1 | 0.023 | 3-oxoacyl-ACP synthase |
| pnig_c_24_1842 | −4.4 | 6.6 | 0.044 | Hemolysin haemolytic protein |
| pnig_c_3_525 | −6.8 | 7.2 | 0.002 | Hypothetical protein |
Abbreviation: CPM, count of mapped reads per gene per million reads.
P values were corrected for false discovary rate using the method by Benjamini and Hochberg.