Table 1.
Distribution of P2 receptors in the renal vascular and tubular structures.
| P2 Receptor | Segment |
|---|---|
| P2X1 | vSMC[9,10,11,12], mTAL[22], CD[23] |
| P2X2 | vSMC[10,11] CD[23] |
| P2X4 | vSMC[11,12], PT[8,11], tDL[8,17], tAL[8], mTAL[8,17,21], DT[8,11], OMCD[23,24] |
| P2X5 | PT[11], mTAL[22], DT[21], CCD[11,23], OMCD[11,23], IMCD[11,23] |
| P2X6 | PT[8,11], tDL[8,11,17], tAL[8,11], mTAL[8,11,17], DT[8,11], CCD[23], OMCD[23], IMCD[23] |
| P2X7 | vSMC[12], Glom[11,12] |
| P2Y1 | vSMC[10,11], Glom[11,13], PT[11,16], tDL[21], mTAL[21], OMCD[16] |
| P2Y2 | vSMC[10], Glom[11,13], PT[11,14,16], tDL[14,16], tAL[14,16], mTAL[14,22], cTAL[14], CD[14], CCD[14], IMCD[14,16], OMCD[14,16] |
| P2Y4 | vSMC[9], Glom[11,13], PT[11,16], tAL[16], mTAL[21], CCD[23], OMCD[23], IMCD[23] |
| P2Y6 | Glom[11,13], PT[15], mTAL[15,22], cTAL[15], CCD[15,23], OMCD[15,23], IMCD[23] |
CCD, cortical collecting duct; CD, collecting duct; cTAL, cortical thick ascending limb; DT, distal tubule; Glom, Glomerulus; IMCD, inner medullary collecting duct; mTAL, medullary thick ascending limb, OMCD, outer medullary collecting duct, PT, proximal tubule, tAL, thin ascending limb; tDL, thin descending limb; vSMC, vascular smooth muscle cell. There is little to no expression reported for P2X3 and P2Y11–14 receptor expression in the kidney.